Clinical Trials Cover

Research Studies

Clinically Proven.
Perfected for You.

At Recova®, we carefully select each ingredient based on robust scientific research and clinical evidence. For more than 30 years, scientists in Guérande, France - working with local universities, have studied local natural resources to harness their health benefits. Our French-made formulations are supported by proven studies to guarantee safety, efficacy, and dependable results.

Sacred Essence™

Sacred Essence™ is the world's only Spirulina extract to have been subjected to a double-blind, placebo-controlled clinical trial on humans. This clinical trial demonstrated, for the first time in humans, the antioxidant activity of a concentrated spirulina extract rich in phycocyanins and polysaccharides. It also highlighted a significant effect on reducing triglycerides and the Fatty Liver Index, indicating broad-spectrum functionality without toxicity.

Sacred Essence™ is currently undergoing a second clinical trial on humans, conducted in a hospitals setting on patients with cancer undergoing chemotherapy.

sacred essence bos

Efficacy of Sacred Essence™ in Reducing Oxidative Stress, Triglyceride Levels, and Improving Liver Health in Individuals with Metabolic Syndrome.

Clinical Study Design Type: Randomized, Double-Blind, Placebo-Controlled Trial, 6 weeks

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Participants: Adults aged 30-65 years with metabolic syndrome*

*With at least three of the following criteria: abdominal obesity, high triglycerides, low HDL cholesterol, high blood pressure, elevated fasting glucose.

Test Method Icon

Test method: Randomization and Blinding

Randomly assigned to either the Sacred Essence or placebo group using a computer-generated randomization sequence.

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Monitoring: Data Safety Interim data reviewed by Monitoring Board

To safeguard participant well-being and integrity of the study, data collection follows standardized procedures and is managed in a secure electronic database.

Spirox Trial Results

Graph Explanation: This graph compares the effects of Sacred Essence™ and a placebo on four health parameters: Oxidative Stress, Triglyceride Levels, Good Cholestrol and the Fatty Liver Index.


Key Results in 90 Days

34.2%
Decrease in urinary isoprostanes was observed (reduction in oxidative stress) vs Placebo

37.6%
Reduction in plasma triglyceride levels (protection against cardiovascular disease) vs Placebo

4.70%
Reduction in the fatty liver index, indicating a potential improvement in liver health and a decrease in liver steatosis from Day 0-90

14.5%
Increase in Good Cholesterol (HDL) vs Placebo

Overall, the graph shows that Sacred Essence™ resulted in more significant improvements than the placebo across all three areas.

Study on Marine Magnesium

The study examines low magnesium levels in pregnant women at a hospital in Nigeria. It found that 16.25% of these women had low magnesium, which was linked to issues like pre-eclampsia (high blood pressure), leg cramps, and early labor. The researchers suggest that increasing magnesium intake through diet or supplements could help prevent these problems.

The study "Natural Magnesium-Enriched Deep-Sea Water Improves Insulin Resistance and the Lipid Profile of Prediabetic Adults: A Randomised, Double-Blinded Crossover Trial" investigated the effects of magnesium-rich deep-sea water on pre-diabetic adults. It found that consumption of this water significantly improved insulin resistance and lipid profiles, suggesting its potential as a natural intervention for managing pre-diabetes. The trial's double-blind, crossover design ensures robust results, highlighting the benefits of magnesium-enriched water in metabolic health.

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Antioxidant Efficacy of a Spirulina Liquid Extract on Oxidative Stress Status and Metabolic Disturbances in Subjects with Metabolic Syndrome

The study evaluates the effect of the Arthrospira liquid extract “Spirulysat®” on oxidative markers—in particular, oxidized LDL (oxLDL)/total LDL cholesterol—and isoprostanes and investigates its impact on lipid and glucose metabolism in the metabolic syndrome subject.

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Combined Effects of Spirulina Liquid Extract and Endurance Training on Aerobic Performance and Muscle Metabolism Adaptation in Wistar Rats

Latest research publication on the benefits of Spirulina extract (Spirulysat) in sports.

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Clinical Trials in Progress for Gastrointestinal Cancer Support

Exploring Phycocyanin’s potential to reduce oxaliplatin-induced neuropathy and improve recovery in metastatic gastrointestinal cancer treatment.

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Sacred Shine™

The synergistic combination of Marine-sourced Magnesium and Cartidyss® - hydrolysed type II collagen peptides makes Sacred Shine™ a highly bioavailable and effective dietary supplement. It is 100% natural, and particularly efficient in improving joint comfort and reducing associated pain.

Sacred Shine™ supports healthy skin aging. Cartidyss™ is composed of collagen peptides and glycosaminoglycans (GAGs) which are responsible for maintaining our skin structure, hydration, and its mechanical properties.

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Efficacy and Safety of Sacred Shine™
on Skin and Joint Health in Middle-Aged Adults

Clinical Study Design Type: Randomized, Double-Blind, Placebo-Controlled Trial, 12 weeks

Objective: Evaluate effectiveness of collagen peptides (PCP and BCP) for managing knee osteoarthritis (OA)

Primary endpoints: WOMAC, VAS, and QOL score changes from baseline to Week 13

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Participants: 30 subjects aged 30-65 years diagnosed with knee OA

*Visual analogue scale (VAS) score ≥40 and Kellgren-Lawrence grade 2-4. 7-day placebo run-in period prior to randomization.

Test Method Icon

Test method: Randomization and Blinding via Computer-generated randomization using SAS® software

2:1 randomization ratio: 20 subjects received PCP or BCP, 10 received placebo. Double-blinded study (neither participants nor researchers knew the group.

Monitoring Icon

Monitoring: Independent Data Monitoring Committee (DMC)

Regular monitoring of safety, including blood and urine analyses. Vital signs (temperature, pulse rate, blood pressure) measured at each visit. Adverse events documented and managed appropriately.

Statistical Analysis:

- Paired Student t-tests and Mann-Whitney U-tests applied

- Confidence level: 95%

- p < 0.01 considered statistically significant for comparing treatment groups and placebo

Perceived Skin Benefits

Graph Explanation: This graph compares the effects of Cartidyss™ with placebo on four skin parameters: Wrinkles, Tonus (Skin Tone), Firmness, and Hydration after 90 days of supplementation at 500mg/day.


Key Results in Skin Health

50%
Reduction in joint pain and improved mobility by reducing cartilage inflammation

26%
Visibly reduces wrinkles by 26% and plumps the skin by boosting elastin and hyaluronic acid production

38%
Improves skin density contributes to a more robust skin matrix, providing better support and structure

10%
Improves thickness of the skin which is indicative of increased collagen deposition and overall skin health

Overall, the graph shows that Sacred Shine™ resulted in more significant improvements than the placebo across all four areas.

Cartidyss™

Cartidyss™ supports healthy aging, mobility, and joint health. Composed of collagen peptides and glycosaminoglycans (GAGs), it plays a crucial role in maintaining skin structure, hydration, and prevents from collagen age-related natural degradation. A recent clinical study demonstrated that after 90 days of supplementation at a low dosage of 500mg/day, Cartidyss™ improved dermis density by 39% compared to placebo, significantly reduced wrinkles, and enhanced skin flexibility and viscoelasticity. Additionally, it helped retain hydration in deeper skin layers, improved dermis hydration, reduced pore size, and achieved a remarkable 50% reduction in joint pain, contributing to overall mobility and well-being.

Improved Mobility and Reduced Pain.

1. Reduction of Pain Over Time (Left Y-Axis, Red)

Placebo Group: Represented by the red solid line with circles. Shows a gradual decrease in pain over the weeks from W2 to W8.

Marine Collagen Group: Represented by the red dashed line with circles. Indicates a significant and more rapid reduction in pain compared to the placebo group, with pain levels dropping sharply by week W8.

2. Improved Mobility Over Time (Right Y-Axis, Blue)

Placebo Group: Represented by the blue solid line with crosses. Shows a slow and steady increase in weight-bearing capacity from W2 to W8.

Marine Collagen Group: Represented by the blue dashed line with crosses. Demonstrates a much steeper increase in weight-bearing capacity, reaching high levels by W6 and maintaining them through W8.

The graph clearly shows that Marine Collagen Hydrolysates are more effective than the placebo in both reducing pain and improving mobility over the eight-week period. The rapid improvement in the Marine Collagen group suggests significant benefits for joint health and muscle comfort.

Collagen Supplementation for Joint Health: The Link between Composition and Scientific Knowledge

Studies on Cartidyss

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The Use of Collagen Hydrolysates and Native Collagen in Osteoarthritis

The study reviews how collagen supplements can help joint health. It found that certain types of collagen, like hydrolysed collagen peptides, can reduce joint pain and improve movement, especially for people with osteoarthritis. The research also points out that knowing the details of how these supplements are made and absorbed by the body is important for getting the best results.

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